NFL odds, lines, picks, spreads, bets, predictions for Week 12, 2023: Model backing Vikings, Titans

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Top overall pick Bryce Young's lone pro victory came against fellow rookie C.J. Stroud and Houston in Week 8, and he'll get another chance to best a fellow member of his draft class on Sunday. Young and the Panthers take on rookie quarterback Will Levis and the Titans, with Tennessee favored by 3.5 points in the Week 12 NFL odds. That's one of several intriguing quarterback battles in the Week 12 NFL schedule, with another matching up former No. 1 overall picks in Matthew Stafford and Kyler Murray. The Rams are one-point road favorites in the NFL spreads and will attract plenty of Week 12 NFL bets since L.A. has won eight straight at Arizona.

However, the Cardinals have covered in four of five home games in 2023, and they haven't lost against the spread in Murray's two games this year. When there are NFL betting trends to support both teams for Week 12 NFL predictions, it wouldn't hurt to have some help with your NFL betting strategy. All of the Week 12 NFL lines are listed below, and SportsLine's advanced computer model has all the NFL betting advice and NFL predictions you need to make the best Week 12 NFL picks now.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 12 of the 2023 NFL season on an incredible 175-126 run on top-rated NFL picks that dates back to the 2017 season. It is also on a 29-18 roll on top-rated NFL picks since Week 7 of last season.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.

Now, it has turned its attention to the latest Week 12 NFL odds and locked in picks for every NFL matchup. Head here to see every pick.

Top Week 12 NFL predictions

We can tell you one of the model's strongest Week 12 NFL picks is that the Vikings (-3.5) cover against the Bears. Minnesota is averaging more points per game since Kirk Cousins was lost for the season, while the defense has been one of the best in the league. Minnesota is giving up just 18 points per game over its last six contests, with multiple takeaways in four of those six games. For the season, the Vikings rank in the top 10 in total yards allowed, with top-seven rankings in both rushing yards allowed and yards per carry given up.

That strong run defense will make it tough sledding for a one-dimensional Bears offense that ranks 25th in passing. Chicago's three wins have come against under .500 teams, while it is 0-5 versus teams currently at or above .500. The Vikings (6-5) fall into the latter, and they already both won and covered at Chicago in Week 6. SportsLine's model foresees a similar outcome in Week 12, with Minnesota (-3.5) covering nearly 60% of the time. See which other teams to pick here.

Another one of its Week 12 NFL predictions: The Titans (-3.5) cover the spread at home versus the Panthers. Titans rookie quarterback Will Levis was sensational in his one home game this year, which was the first game of his NFL career. He had four touchdowns and no picks in a Week 7 win over Atlanta before going on the road for each of the past three weeks and with a 2:2 TD:INT over that stretch.

Meanwhile, Young has predictably struggled on the road, with multiple interceptions in two away starts and one or no touchdown passes in his other two road starts. The model projects Young to have fewer touchdown passes and a lower completion percentage than Levis, while the top pick has more passing yards only due to Carolina playing catchup. Levis and Tennessee prevail as 3.5-point favorites in this matchup well over 50% of the time, with the Over (37) hitting in over 50% of simulations. See which other teams to pick here.

How to make Week 12 NFL picks

The model has also made the call on who wins and covers in every other game on the Week 12 NFL schedule and also just revealed three must-see underdogs who win outright. You can only get every pick for every game at SportsLine.

So what NFL picks can you make with confidence, and which underdogs should you pick right now? Check out the latest NFL odds below, then visit SportsLine to see which teams win and cover the spread, all from a proven computer model that has returned well over $7,000 since its inception, and find out.